Amyloid deposition in Alzheimer's disease.
نویسندگان
چکیده
Alzheimer's disease (AD), a progressive neurodegenerative disorder, accounts for approximately 60 percent of all victims of dementia and affects greater than 10 percent of the population over 65 years old. Although the cause is unknown, there is evidence that beta-amyloid plays an important role in its pathogenesis. The deposition of this type of amyloid in the brain and its implications in AD are discussed.
منابع مشابه
Effect of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields on β-amyloid Deposition and Microglia Cells in an Alzheimer Model in Rats
Background: Recently, researchers have considered extremely low-frequency electromagnetic fields (ELF-EMFs), as one of the non-invasive therapies, in the treatment of many severe neurological disorders, including Alzheimer Disease (AD). AD is a progressive neurodegenerative disease characterized by the deposition of amyloid plaques in the brain. However, the increase in microglial cells increas...
متن کاملCholinergic neuropathology in a mouse model of Alzheimer's disease
Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...
متن کاملCholinergic neuropathology in a mouse model of Alzheimer's disease
Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...
متن کاملP135: The Role of Amyloid Beta-Peptides and Tau Protein in Alzheimer\'s Disease
Alzheimer's desease is the most common age-related neurodegenerative disorder, and cognitive problems such as defects in learning and memory are of its symptoms. Among the factors involved in the pathogenesis of the disease are biochemical disorders in protein production, oxidative stress, decreased acetylcholine secretion and inflammation of the brain tissue. Extra-neuronal accumulation ...
متن کاملThe Effect of Endurance Training on the Expression of PRDX6 and KAT2B Genes in Hippocampus of Beta Amyloid-Induced Rat Model of Alzheimer's Disease: An Experimental Study
Background and Objectives: Alzheimer's disease is the most common form of dementia. KAT2B (Lysine Acetyltransferase 2B) is a mitochondrial protein known as mitochondria clearing control organ by mitophagy. PRDX6 (Peroxiredoxin 6) is a key regulator of mitophagy and plays a critical role in maintaining mitochondrial ROS (Reactive oxygen species) homeostasis. Therefore, the purpose of this study ...
متن کاملThe Bad Seed in Alzheimer’s Disease
In this issue of Neuron, McGowan et al. report on a new mouse model of amyloid deposition as occurs in Alzheimer's disease. Unlike previous models in which overexpression of the amyloid precursor protein results in amyloid plaque formation, McGowan et al. have produced mice that overexpress only Abeta40 or Abeta42 and prove that Abeta42 is critical for the formation of amyloid deposits in vivo.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Annals of clinical and laboratory science
دوره 23 3 شماره
صفحات -
تاریخ انتشار 1993